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Proof-of-concept for a virus-induced obesity vaccine; vaccination against the obesity agent adenovirus 36.
- Source :
-
International Journal of Obesity . Nov2014, Vol. 38 Issue 11, p1470-1474. 5p. - Publication Year :
- 2014
-
Abstract
- Human adenovirus 36 (Ad36) is positively associated with obesity in humans and animals. Ad36 infection is characterized by increased adiposity and inflammation. To investigate the possibility that a prophylactic vaccine candidate might protect against Ad36-induced obesity and inflammation, we purified Ad36 and ultraviolet-irradiated virus to obtain a vaccine candidate. After immunizing the mice with the vaccine candidate (vaccinated group), live Ad36 was injected into mice as a challenge test. Unvaccinated mice (control group) were immunized with phosphate-buffered saline and then challenged with live Ad36. Fourteen weeks after challenge, we compared adiposity and inflammation in vaccinated and control mice. The control group showed 17% greater body weight and 20% more epididymal fats compared with the vaccinated group. In addition, the vaccinated group had decreased serum levels of pro-inflammatory cytokines, and infiltrated immune cells, especially M1 macrophages, in fat tissue. Therefore, the vaccine candidate for Ad36 was able to protect against Ad36-increased body weight and fat as well as inflammatory states after challenge. These results provide proof-of-concept for prophylactic vaccination against virus-induced adiposity. [ABSTRACT FROM AUTHOR]
- Subjects :
- *HUMAN adenoviruses
*OBESITY
*INFLAMMATION
*VACCINE research
*CYTOKINES
Subjects
Details
- Language :
- English
- ISSN :
- 03070565
- Volume :
- 38
- Issue :
- 11
- Database :
- Academic Search Index
- Journal :
- International Journal of Obesity
- Publication Type :
- Academic Journal
- Accession number :
- 99362582
- Full Text :
- https://doi.org/10.1038/ijo.2014.41