Evaluation of enzyme inhibition kinetics in drug–drug interactions.

Inhibition of CYP enzymes is thought to be the most common cause of drug–drug and/or herb–drug interactions. To characterize the inhibition of CYP enzymes activities by chemicals, enzyme inhibition kinetic experiments are usually carried out. The purpose of this letter is to call attention to evaluate the enzyme inhibition kinetics in drug–drug interactions. [ABSTRACT FROM AUTHOR]