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Improved robotic stereotactic body radiation therapy plan quality and planning efficacy for organ-confined prostate cancer utilizing overlap-volume histogram-driven planning methodology.
- Source :
-
Radiotherapy & Oncology . Aug2014, Vol. 112 Issue 2, p221-226. 6p. - Publication Year :
- 2014
-
Abstract
- Background and purpose This study is to determine if the overlap-volume histogram (OVH)-driven planning methodology can be adapted to robotic SBRT (CyberKnife Robotic Radiosurgery System) to further minimize the bladder and rectal doses achieved in plans manually-created by clinical planners. Methods and materials A database containing clinically-delivered, robotic SBRT plans (7.25 Gy/fraction in 36.25 Gy) of 425 patients with localized prostate cancer was used as a cohort to establish an organ’s distance-to-dose model. The OVH-driven planning methodology was refined by adding the PTV volume factor to counter the target’s dose fall-off effect and incorporated into Multiplan to automate SBRT planning. For validation, automated plans (APs) for 12 new patients were generated, and their achieved dose/volume values were compared to the corresponding manually-created, clinically-delivered plans (CPs). A two-sided, Wilcoxon rank-sum test was used for statistical comparison with a significance level of p < 0.05. Results PTV’s V (36.25 Gy) was comparable: 95.6% in CPs comparing to 95.1% in APs ( p = 0.2). On average, the refined approach lowered V (18.12 Gy) to the bladder and rectum by 8.2% ( p < 0.05) and 6.4% ( p = 0.14). A physician confirmed APs were clinically acceptable. Conclusions The improvements in APs could further reduce toxicities observed in SBRT for organ-confined prostate cancer. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 01678140
- Volume :
- 112
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Radiotherapy & Oncology
- Publication Type :
- Academic Journal
- Accession number :
- 99508067
- Full Text :
- https://doi.org/10.1016/j.radonc.2014.07.009