Back to Search
Start Over
Immunopathogenesis of chlamydia trachomatis infections in women
- Source :
-
Fertility & Sterility . Jun2003, Vol. 79 Issue 6, p1273-1287. 15p. - Publication Year :
- 2003
-
Abstract
- : ObjectiveTo develop a model of pathogenesis by which Chlamydia trachomatis progresses from acute to chronic infection, and finally serious disease (salpingitis, tubal occlusion).: DesignReview of current literature located through web-based Medline searches using key words: Chlamydia trachomatis, immunology, cytokines, heat shock protein, infertility.: Result(s)Cell-mediated immune mechanisms appear to be critical in determining whether acute infection is resolved or progresses into chronicity with pathological outcome. What determines the particular immune pathway depends on a range of determinants—HLA subtype and human genetics, cytokine profile, infectious load, route of infection, and endocrinology. A clearer picture of the natural history of chlamydial pathology may assist in providing better predictors of those women who may go on to develop significant sequelae after infection.: Conclusion(s)Predicting those who may develop serious disease, including infertility, may contribute to improved management of such persons during earlier stages of infection and assist in prevention. [Copyright &y& Elsevier]
- Subjects :
- *CHLAMYDIA trachomatis
*INFERTILITY
Subjects
Details
- Language :
- English
- ISSN :
- 00150282
- Volume :
- 79
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Fertility & Sterility
- Publication Type :
- Academic Journal
- Accession number :
- 9952853
- Full Text :
- https://doi.org/10.1016/S0015-0282(03)00396-0