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Glypican-4 is increased in human subjects with impaired glucose tolerance and decreased in patients with newly diagnosed type 2 diabetes.
- Source :
-
Acta Diabetologica . Dec2014, Vol. 51 Issue 6, p981-990. 10p. - Publication Year :
- 2014
-
Abstract
- Context: Glypican-4 (GPC-4) has been identified as a novel adipokine capable of enhancing insulin signaling. A significant association between circulating GPC-4 levels and nonalcoholic fatty liver disease and cardiometabolic risk factors has been found in women. Objective: The aim of the present study was to investigate the relationship between GPC-4 and insulin resistance in cross-sectional and interventional studies. Patients and design: We measured circulating GPC-4 (determined with ELISA) in subjects with NGT, IGT, and nT2DM. Euglycemic-hyperinsulinemic clamps were performed in healthy and T2DM subjects. Real-time RT-PCR and Western blotting were used to assess mRNA and protein expression of GPC-4. Results: Circulating GPC-4 levels were significantly higher in IGT subjects and lower in nT2DM subjects compared to controls. Circulating GPC-4 was positively correlated with BMI, WHR, HOMA-IS, and FAT%, while it was inversely correlated with FBG and HbA1c. Excluding diabetic subjects, increasing GPC-4 levels were associated with HOMA-IR and M values. Significantly lower GPC-4 mRNA and protein levels were found in muscle and fat of nT2DM patients, compared to controls. GPC-4 levels were significantly increased upon an oral glucose intake. The secretion of GPC-4 exhibited a characteristic diurnal rhythm in humans, with a major rise occurring between afternoon and midnight. Conclusions: Circulating GPC-4 is elevated in prediabetic subjects and is reduced in nT2DM patients. The elevated GPC-4 appears to be associated with insulin resistance and obesity in IGT subjects. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09405429
- Volume :
- 51
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Acta Diabetologica
- Publication Type :
- Academic Journal
- Accession number :
- 99567981
- Full Text :
- https://doi.org/10.1007/s00592-014-0652-5