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Zeo-Click Synthesis: Copper-Zeolite-Catalyzed Synthesis of Ynamides.
- Source :
-
Advanced Synthesis & Catalysis . Dec2014, Vol. 356 Issue 18, p3842-3848. 7p. - Publication Year :
- 2014
-
Abstract
- Copper(I)-zeolites, especially copper(I)-ultra stable Y zeolite (USY), are very efficient heterogeneous catalysts for the coupling of functionalized 1-bromoalkynes and various nitrogen derivatives. Under these conditions, sulfonylated alkyl- or arylamines and various N-heterocycles, such as oxazolidinones or indoles, could be efficiently transformed into the corresponding N-alkynyl derivatives. However, imidazoles gave addition products rather than coupling products. The reaction conditions proved compatible with a variety of functional and protecting groups. Such zeolitic catalysts can be recycled and reused at least five times without significant deactivation. Low catalyst loading could be used (4 mol%) and as low as 0.8 mol% of this heterogeneous copper catalyst still gave good conversion and yields. [ABSTRACT FROM AUTHOR]
- Subjects :
- *YNAMIDES
*COPPER
*ALKYNES
*TRANSITION metals
*CATALYSIS
Subjects
Details
- Language :
- English
- ISSN :
- 16154150
- Volume :
- 356
- Issue :
- 18
- Database :
- Academic Search Index
- Journal :
- Advanced Synthesis & Catalysis
- Publication Type :
- Academic Journal
- Accession number :
- 99802494
- Full Text :
- https://doi.org/10.1002/adsc.201400189