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Synthesis of the carbon skeleton of the griseorhodins.
- Source :
-
Tetrahedron . Jan2015, Vol. 71 Issue 1, p91-101. 11p. - Publication Year :
- 2015
-
Abstract
- A synthetic strategy to access the carbon skeleton of the griseorhodin family of natural products has been developed. The key step involved the acid-mediated spirocyclisation of a highly functionalised dihydroxyketone. The delicate electronic balance between the electron rich naphthalene moiety and the electron-withdrawing isocoumarin ring system were finely tuned to facilitate the acid-mediated spirocyclisation reaction. The development of this synthetic strategy provides a basis for further synthetic investigations towards the more structurally complex griseorhodin natural products. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00404020
- Volume :
- 71
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Tetrahedron
- Publication Type :
- Academic Journal
- Accession number :
- 99894821
- Full Text :
- https://doi.org/10.1016/j.tet.2014.11.030