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Ionic starch-based hydrogels for the prevention of nonspecific protein adsorption.
- Source :
-
Carbohydrate Polymers . Mar2015, Vol. 117, p384-391. 8p. - Publication Year :
- 2015
-
Abstract
- Non-fouling materials bind water molecules via either hydrogen bonding or ionic solvation to form a hydration layer which is responsible for their resistance to protein adsorption. Three ionic starch-based polymers, namely a cationic starch (C-Starch), an anionic starch (A-Starch) and a zwitterionic starch (Z-Starch), were synthesized via etherification reactions to incorporate both hydrogen bonding and ionic solvation hydration groups into one molecule. Further, C-, A- and Z-Starch hydrogels were prepared via chemical crosslinking. The non-fouling properties of these hydrogels were tested with different proteins in solutions with different ionic strengths. The C-Starch hydrogel had low protein resistance at all ionic strengths; the A-Starch hydrogel resisted protein adsorption at ionic strengths of more than 10 mM; and the Z-Starch hydrogel resisted protein adsorption at all ionic strengths. In addition, the A- and Z-Starch hydrogels both resisted cell adhesion. This work provides a new path for developing non-fouling materials using the integration of polysaccharides with anionic or zwitterionic moieties to regulate the protein resistance of materials. [ABSTRACT FROM AUTHOR]
- Subjects :
- *IONIC liquids
*STARCH
*HYDROGELS
*PROTEIN analysis
*HYDROGEN bonding
*HYDRATION
Subjects
Details
- Language :
- English
- ISSN :
- 01448617
- Volume :
- 117
- Database :
- Academic Search Index
- Journal :
- Carbohydrate Polymers
- Publication Type :
- Academic Journal
- Accession number :
- 99918714
- Full Text :
- https://doi.org/10.1016/j.carbpol.2014.09.077