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Determinants in chemosensitivity of oncogene-transformed NIH3T3 cells to 2'-C-cyano-2'-deoxy-1-beta-D-arabinofuranosylcytosine.
- Source :
-
International journal of oncology [Int J Oncol] 1999 Mar; Vol. 14 (3), pp. 543-9. - Publication Year :
- 1999
-
Abstract
- 2'-C-Cyano-2'-deoxy-1-beta-D-arabinofuranosylcytosine (CNDAC) is a novel 2'-deoxycytidine (dCyd) analogue with potent antitumor activity. To elucidate the determinants of chemosensitivity to CNDAC, the intracellular accumulation of CNDAC and the activities of dCyd kinase and cytidine deaminase were investigated in transformed NIH 3T3 cells with different genetic bases. The results indicate that the primary determinants of chemosensitivity to CNDAC are different in each cell type, but membrane transportation and the enzyme activities of dCyd kinase and cytidine deaminase are critical factors underlying the antitumor action of CNDAC. Moreover, the expression or function of these factors appears to be influenced by the activation of various oncogenes.
- Subjects :
- 3T3 Cells
Animals
Antineoplastic Agents metabolism
Cell Division drug effects
Cell Transformation, Neoplastic
Chick Embryo
Cytarabine metabolism
Cytarabine pharmacology
Cytidine Deaminase metabolism
Deoxycytidine Kinase metabolism
Mice
Mice, Nude
Neoplasm Transplantation
Neoplasms, Experimental enzymology
Neoplasms, Experimental metabolism
Neoplasms, Experimental pathology
Oncogenes
Transformation, Genetic
Tritium
Antineoplastic Agents pharmacology
Cytarabine analogs & derivatives
Subjects
Details
- Language :
- English
- ISSN :
- 1019-6439
- Volume :
- 14
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- International journal of oncology
- Publication Type :
- Academic Journal
- Accession number :
- 10024689