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NKp44, a triggering receptor involved in tumor cell lysis by activated human natural killer cells, is a novel member of the immunoglobulin superfamily.
- Source :
-
The Journal of experimental medicine [J Exp Med] 1999 Mar 01; Vol. 189 (5), pp. 787-96. - Publication Year :
- 1999
-
Abstract
- Surface receptors involved in natural killer (NK) cell triggering during the process of tumor cell lysis have recently been identified. Of these receptors, NKp44 is selectively expressed by IL-2- activated NK cells and may contribute to the increased efficiency of activated NK cells to mediate tumor cell lysis. Here we describe the molecular cloning of NKp44. Analysis of the cloned cDNA indicated that NKp44 is a novel transmembrane glycoprotein belonging to the Immunoglobulin superfamily characterized by a single extracellular V-type domain. The charged amino acid lysine in the transmembrane region may be involved in the association of NKp44 with the signal transducing molecule killer activating receptor-associated polypeptide (KARAP)/DAP12. These molecules were found to be crucial for the surface expression of NKp44. In agreement with data of NKp44 surface expression, the NKp44 transcripts were strictly confined to activated NK cells and to a minor subset of TCR-gamma/delta+ T lymphocytes. Unlike genes coding for other receptors involved in NK cell triggering or inhibition, the NKp44 gene is on human chromosome 6.
- Subjects :
- Adaptor Proteins, Signal Transducing
Amino Acid Sequence
Animals
COS Cells
Cell Compartmentation
Chromosomes, Human, Pair 6
Cloning, Molecular
Conserved Sequence
DNA, Complementary genetics
Humans
Immunoglobulins classification
Immunoglobulins immunology
Immunoglobulins metabolism
Lymphocyte Subsets immunology
Membrane Proteins
Mice
Molecular Sequence Data
Natural Cytotoxicity Triggering Receptor 2
Protein Binding
RNA, Messenger isolation & purification
Receptors, Immunologic classification
Receptors, Immunologic immunology
Receptors, Immunologic metabolism
Sequence Homology, Amino Acid
Signal Transduction
Species Specificity
Cytotoxicity, Immunologic
Immunoglobulins genetics
Killer Cells, Natural immunology
Receptors, Immunologic genetics
Subjects
Details
- Language :
- English
- ISSN :
- 0022-1007
- Volume :
- 189
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- The Journal of experimental medicine
- Publication Type :
- Academic Journal
- Accession number :
- 10049942
- Full Text :
- https://doi.org/10.1084/jem.189.5.787