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[Induction of antitumor immune response in the mouse model after vaccination with B7.1 expressing tumor cells].
- Source :
-
Laryngo- rhino- otologie [Laryngorhinootologie] 1999 Jan; Vol. 78 (1), pp. 36-40. - Publication Year :
- 1999
-
Abstract
- The aim of the study was the induction of an antitumor immune response by genetic modification of tumor cells. This was done by transfecting the costimulatory molecule B7.1 into a murine tumor cell line SCCVII/SF in order to increase T cell recognition and to install an immunologic memory. One cohort of immunocompetent mice C3 H/HeN were injected with B7.1 expressing tumor cells, while the control group received parental B7.1 negative tumor cells. In a second step those immunized mice were rechallenged by parental tumor cells and tumor growth was compared to a new control group. Transfection with B7.1 prohibits outgrowth of the SCCVII cell line. Animals that have been vaccinated in this way are partially immune towards a secondary exposition to B7.1 negative tumor cells. Outgrowth of this recurrent tumor is slowed down. Such an immunization builds up an immunologic memory. Vaccination with B7.1 expressing tumor cells lead to a partial protective tumor immunity in the SCCVII-C3 H/HeN mouse model.
- Subjects :
- Animals
Cancer Vaccines administration & dosage
Carcinoma, Squamous Cell therapy
Cell Line, Transformed
Genetic Therapy
Humans
Immunologic Memory immunology
Mice
Mice, Inbred C3H
Neoplasm Invasiveness
Otorhinolaryngologic Neoplasms therapy
Tumor Cells, Cultured
Cancer Vaccines immunology
Carcinoma, Squamous Cell immunology
Otorhinolaryngologic Neoplasms immunology
Subjects
Details
- Language :
- German
- ISSN :
- 0935-8943
- Volume :
- 78
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Laryngo- rhino- otologie
- Publication Type :
- Academic Journal
- Accession number :
- 10080127
- Full Text :
- https://doi.org/10.1055/s-2007-996826