Back to Search
Start Over
Influence of human immunodeficiency virus infection on chronic hepatitis B in homosexual men.
- Source :
-
Hepatology (Baltimore, Md.) [Hepatology] 1999 Apr; Vol. 29 (4), pp. 1306-10. - Publication Year :
- 1999
-
Abstract
- The aim of this study was to assess the influence of human immunodeficiency virus (HIV) infection on chronic hepatitis B. In a series of 132 (65 anti-HIV positive) homosexual non-drug addicted men with chronic hepatitis B, the liver function was assessed with biochemical tests; the degree of hepatitis B virus (HBV) replication was assessed with serum HBV DNA level and with immunoperoxidase staining of hepatitis B core (HBc) antigen on liver specimens; and the severity of liver lesions was assessed with an histology activity index. Anti-HIV-positive and anti-HIV-negative patients were not different for serum aspartate transaminase activity, bilirubin, prothrombin, and histology activity index. Anti-HIV-positive patients had lower serum alanine transaminase activity levels (P =.0001), lower serum albumin levels (P =.0009), and higher serum HBV DNA levels (P =.01). There was a higher prevalence of cirrhosis in anti-HIV-positive patients (P =.04). In homosexual men with chronic hepatitis B, HIV infection is associated with a higher level of HBV replication and a higher risk for cirrhosis without increased liver necrotico-inflammatory process.
- Subjects :
- Alanine Transaminase blood
Biopsy
DNA, Viral blood
HIV Infections blood
Hepatitis B e Antigens blood
Hepatitis B virus growth & development
Hepatitis B virus metabolism
Hepatitis B, Chronic blood
Hepatitis B, Chronic metabolism
Humans
Liver Cirrhosis complications
Liver Cirrhosis metabolism
Liver Cirrhosis virology
Liver Function Tests
Male
Risk Factors
Serum Albumin metabolism
HIV Infections complications
Hepatitis B, Chronic complications
Homosexuality, Male
Subjects
Details
- Language :
- English
- ISSN :
- 0270-9139
- Volume :
- 29
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Hepatology (Baltimore, Md.)
- Publication Type :
- Academic Journal
- Accession number :
- 10094979
- Full Text :
- https://doi.org/10.1002/hep.510290447