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Type I (insulin-dependent) diabetes mellitus and cow milk: casein variant consumption.
- Source :
-
Diabetologia [Diabetologia] 1999 Mar; Vol. 42 (3), pp. 292-6. - Publication Year :
- 1999
-
Abstract
- Previously published Type I (insulin-dependent) diabetes mellitus incidence in 0 to 14-year-old children from 10 countries or areas was compared with the national annual cow milk protein consumption. Countries which were selected for study had appropriate milk protein polymorphism studies, herd breed composition information and low dairy imports from other countries. Total protein consumption did not correlate with diabetes incidence (r = +0.402), but consumption of the beta-casein A1 variant did (r = +0.726). Even more pronounced was the relation between beta-casein (A1+B) consumption and diabetes (r = +0.982). These latter two cow caseins yield a bioactive peptide beta-casomorphin-7 after in vitro digestion with intestinal enzymes whereas the common A2 variant or the corresponding human or goat caseins do not. beta-casomorphin-7 has opioid properties including immunosuppression, which could account for the specificity of the relation between the consumption of some but not all beta-casein variants and diabetes incidence.
- Subjects :
- Adolescent
Amino Acid Sequence
Animals
Canada epidemiology
Caseins genetics
Cattle
Child
Child, Preschool
Diabetes Mellitus, Type 1 etiology
Endorphins chemistry
Europe epidemiology
Female
Genetic Variation
Humans
Incidence
Infant
Milk chemistry
Milk Proteins
New Zealand epidemiology
Peptide Fragments chemistry
United States epidemiology
Caseins adverse effects
Caseins chemistry
Diabetes Mellitus, Type 1 epidemiology
Milk adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 0012-186X
- Volume :
- 42
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Diabetologia
- Publication Type :
- Academic Journal
- Accession number :
- 10096780
- Full Text :
- https://doi.org/10.1007/s001250051153