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Levodropropizine (LD) activity in allergic asthmatic patients, challenged with ultrasonically nebulized distilled water, metacholine and allergen-induced bronchospasm.
- Source :
-
Clinical trials and meta-analysis [Clin Trials Metaanal] 1994 Apr; Vol. 29 (1), pp. 9-20. - Publication Year :
- 1994
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Abstract
- The antitussive compound Levodropropizine (LD) is active in animal bronchoconstriction induced by histamine and capsaicin and in man protects from bronchoconstriction induced by capsaicin. The primary objective of this study was to evaluate the mechanism of action of LD given at 60 mg t.i.d. as oral drops, for 8 days by means of specific bronchial challenges (allergens) and of aspecific challenges acting via different receptors and fibers (i.e. metacholine via cholinergic receptors and ultrasonically nebulized distilled water (UNDW) via histamine and neuropeptide release). The study design is randomized, double-blind, cross-over versus placebo in 30 allergic asthmatic patients. Baseline bronchial tone and bronchoconstrictor response to metacholine (MCh) were not modified by active treatment nor by placebo. On the contrary, in airway responsiveness to UNDW, the active treatment showed an antagonist effect against induced bronchoconstriction of 59% [activity ratio (AR) as antilog = 0.41; 95% confidence interval 0.35-0.54; p < or = 0.05] in comparison to no effect for placebo. Similarly, in airway responsiveness to specific allergen, active treatment antagonized the bronchoconstrictor effect of grass pollen by 83% and of various allergens (dermatophagoides and grass pollen) by 72%, i.e. AR of 0.17 (95% confidence interval 0.045-0.65; p < 0.01) and of 0.28 (95% confidence interval 0.07-1.04; p < 0.05), respectively. No antagonist effect was evident with placebo at all times. Besides inhibiting cough, LD is also partially effective in inhibiting bronchial hyperreactive response against specific allergen and UNDW bronchoconstriction. Hence, LD might act by partly inhibiting histamine and neuropeptide release.
- Subjects :
- Administration, Oral
Adolescent
Adult
Antitussive Agents administration & dosage
Antitussive Agents pharmacology
Bronchial Hyperreactivity prevention & control
Bronchial Provocation Tests
Cross-Over Studies
Double-Blind Method
Female
Humans
Male
Middle Aged
Nebulizers and Vaporizers
Placebos
Propylene Glycols administration & dosage
Propylene Glycols pharmacology
Ultrasonic Therapy
Water
Allergens
Antitussive Agents therapeutic use
Asthma prevention & control
Bronchial Spasm prevention & control
Hypersensitivity prevention & control
Methacholine Chloride
Propylene Glycols therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 0927-5401
- Volume :
- 29
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Clinical trials and meta-analysis
- Publication Type :
- Academic Journal
- Accession number :
- 10184318