Back to Search
Start Over
Synthesis of glucuronides of multidrug resistance reversing drug MS-209.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 1999 Mar 08; Vol. 9 (5), pp. 659-62. - Publication Year :
- 1999
-
Abstract
- We synthesized the glucuronides of MS-209 to identify the two main unknown metabolites in human urine. Reaction of MS-209 and glucuronyl trichloroacetimidate gave two beta-isomers, which were each glucuronate of (R)- and (S)-MS-209. These spectrum data were identical with the metabolites.
- Subjects :
- Antineoplastic Agents chemistry
Antineoplastic Agents pharmacokinetics
Antineoplastic Agents urine
Drug Resistance, Neoplasm physiology
Glucuronates metabolism
Glucuronates pharmacology
Glucuronates urine
Humans
Quinolines chemistry
Quinolines pharmacokinetics
Quinolines urine
Antineoplastic Agents metabolism
Drug Resistance, Multiple
Glucuronates chemical synthesis
Quinolines metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0960-894X
- Volume :
- 9
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 10201824
- Full Text :
- https://doi.org/10.1016/s0960-894x(99)00056-6