Back to Search
Start Over
Comparison of serological and parasitological assessments of Onchocerca volvulus transmission after 7 years of mass ivermectin treatment in Mexico.
- Source :
-
Tropical medicine & international health : TM & IH [Trop Med Int Health] 1999 Feb; Vol. 4 (2), pp. 98-104. - Publication Year :
- 1999
-
Abstract
- Objective and Method: To compare the utility of an ELISA using 3 recombinant antigens with that of the skin biopsy to estimate incidence of infections in a sentinel cohort of individuals living in an endemic community in southern Mexico during a set of 11 subsequent ivermectin treatments.<br />Results: The apparent community prevalence of infection and microfilarial skin infection before and after 11 treatments with ivermectin plus nodulectomy were 78% and 13%, and 0.68 mf/mg and 0.04 mf/mg, respectively, as measured by skin biopsy. Of a group of 286 individuals participating in all surveys, a sentinel cohort of 42 mf and serologically negative individuals had been followed since 1994. The annual percentage of individuals becoming positive in this cohort was 24% (10/42), 28% (9/33), 0%, and 4.3% (1/23) in 1995, 1996, 1997 and 1998, respectively. Likewise, the incidence in children 5 years and under (n = 13) within this sentinel cohort was 15% (2/13), 18% (2/11), 0% and 11% (1/9), respectively. All individuals became positive to both tests simultaneously, indicating that seroconversion assessed infection incidence as accurately as skin biopsy in the sentinel group.<br />Conclusion: Incidence monitoring of a sentinel cohort provides an estimation of the parasite transmission in the community; it is less costly than massive sampling, and a finger prick blood test might be more acceptable in some communities.
- Subjects :
- Adolescent
Adult
Animals
Antibodies, Helminth blood
Antigens, Helminth immunology
Antiparasitic Agents
Child
Child, Preschool
Cohort Studies
Endemic Diseases
Humans
Infant
Infant, Newborn
Longitudinal Studies
Mexico epidemiology
Microfilariae drug effects
Microfilariae isolation & purification
Onchocerca volvulus drug effects
Onchocerca volvulus immunology
Onchocerciasis epidemiology
Onchocerciasis parasitology
Recombinant Proteins immunology
Skin parasitology
Skin Diseases, Parasitic parasitology
Skin Diseases, Parasitic transmission
Enzyme-Linked Immunosorbent Assay
Filaricides therapeutic use
Ivermectin therapeutic use
Onchocerca volvulus isolation & purification
Onchocerciasis drug therapy
Onchocerciasis transmission
Subjects
Details
- Language :
- English
- ISSN :
- 1360-2276
- Volume :
- 4
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Tropical medicine & international health : TM & IH
- Publication Type :
- Academic Journal
- Accession number :
- 10206263
- Full Text :
- https://doi.org/10.1046/j.1365-3156.1999.00363.x