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Investigations on the ability of clenbuterol hydrochloride to reduce clinical signs and inflammation associated with equine influenza A infection.
- Source :
-
Equine veterinary journal [Equine Vet J] 1999 Mar; Vol. 31 (2), pp. 160-8. - Publication Year :
- 1999
-
Abstract
- Twenty-four Quarter Horse and Quarter Horse-cross yearlings were experimentally infected with influenza A virus (Influenza A/equine/Saskatoon/90 [H3N8]) by nebulisation. In a double blind controlled trial the horses were randomly assigned to 3 groups of 8 animals. Group 1 received a placebo, (carrier syrup), Group 2 the labelled dose and Group 3 twice the labelled dose of clenbuterol hydrochloride. All treatments were given per os b.i.d. for 10 days and started on the day of infection. The horses were monitored for clinical signs of influenza infection for 14 days. Bronchoalveolar lavages were performed 4 days prior to, and 5 and 13 days after infection. Cell counts and concentrations of prostaglandin E2 and prostaglandin F2alpha in the lavage fluid were determined. Blood samples for haematology and serology were taken 4 days before, on the day of infection, 5, 9 and 13 days after infection. All horses experienced a typical influenza infection with fever, coughing and secondary bacterial infections with mainly Actinobacillus spp. and Streptococcus spp. There was no statistically or clinically significant effect of treatment with clenbuterol hydrochloride on measured clinical or laboratory parameters within 14 days of infection.
- Subjects :
- Animals
Bronchoalveolar Lavage veterinary
Bronchoalveolar Lavage Fluid microbiology
Bronchoalveolar Lavage Fluid virology
Cough veterinary
Dinoprost analysis
Dinoprostone analysis
Double-Blind Method
Female
Fever veterinary
Horses
Leukocyte Count veterinary
Male
Orthomyxoviridae Infections drug therapy
Adrenergic beta-Agonists therapeutic use
Clenbuterol therapeutic use
Horse Diseases drug therapy
Influenza A virus
Orthomyxoviridae Infections veterinary
Subjects
Details
- Language :
- English
- ISSN :
- 0425-1644
- Volume :
- 31
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Equine veterinary journal
- Publication Type :
- Academic Journal
- Accession number :
- 10213429
- Full Text :
- https://doi.org/10.1111/j.2042-3306.1999.tb03810.x