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Alpha-lipoic acid provides neuroprotection from ischemia-reperfusion injury of peripheral nerve.
- Source :
-
Journal of the neurological sciences [J Neurol Sci] 1999 Feb 01; Vol. 163 (1), pp. 11-6. - Publication Year :
- 1999
-
Abstract
- Background: Reperfusion aggravates nerve ischemic fiber degeneration, likely by the generation of reduced oxygen species. We therefore evaluated if racemic alpha-lipoic acid (LA), a potent antioxidant, will protect peripheral nerve from reperfusion injury, using our established model of ischemia-reperfusion injury.<br />Methods: We used male SD rats, 300+/-5 g. Ischemia was produced by the ligature of each of the supplying arteries to the sciatic-tibial nerve of the right hind-limb for predetermined periods of time (either 3 or 5 h), followed by the release of the ligatures, resulting in reperfusion. LA was given intraperitoneally daily for 3 days for both pre- and post-surgery. Animals received either LA, 100 mg/kg/day, or the same volume of saline intraperitoneally. Clinical behavioral score and electrophysiology of motor and sensory nerves were obtained at 1 week after ischemia-reperfusion. After electrophysiological examination, the sciatic-tibial nerve was fixed in situ and embedded in epon. We evaluated for ischemic fiber degeneration (IFD) and edema, as we described previously.<br />Results: Distal sensory conduction (amplitude of sensory action potential and sensory conduction velocity (SCV) of digital nerve) was significantly improved in the 3-h ischemia group, treated with LA (P<0.05). LA also improved IFD of the mid tibial nerve (P=0.0522). LA failed to show favorable effects if the duration of ischemia was longer (5-h ischemia).<br />Conclusion: These results suggest that alpha-lipoic acid is efficacious for moderate ischemia-reperfusion, especially on distal sensory nerves.
- Subjects :
- Action Potentials
Animals
Gait
Hindlimb blood supply
Ischemia pathology
Male
Muscle, Skeletal innervation
Neuroprotective Agents therapeutic use
Pain
Posture
Rats
Rats, Sprague-Dawley
Reperfusion Injury pathology
Sciatic Nerve pathology
Sciatic Nerve physiopathology
Thioctic Acid therapeutic use
Tibial Nerve pathology
Tibial Nerve physiopathology
Ischemia physiopathology
Neuroprotective Agents pharmacology
Reperfusion Injury prevention & control
Sciatic Nerve blood supply
Thioctic Acid pharmacology
Tibial Nerve blood supply
Subjects
Details
- Language :
- English
- ISSN :
- 0022-510X
- Volume :
- 163
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of the neurological sciences
- Publication Type :
- Academic Journal
- Accession number :
- 10223404
- Full Text :
- https://doi.org/10.1016/s0022-510x(99)00017-9