[Kynurenic acid concentration in blood and urine during normal pregnancy].

Objectives: The aim of the study was to evaluate the concentrations of kynurenic acid (KYNA) in blood and urine during the normal pregnancy.
Materials and Methods: Under the study were 37 pregnant women. Level of KYNA was measured by high performance liquid chromatography (HPLC).
Results: The KYNA concentration in blood serum was 1.56 pmol/100 microliters and in urine -1.17 nmol/100 microliters (6.57 nmol/mg creatinine). The level of KYNA in blood serum did not correlate with the age of pregnancy. Statistically insignificant decrease of KYNA level in urine during the pregnancy was observed.
Conclusions: Decreasing of KYNA level in urine during the pregnancy independently from its blood level was observed. The studies on the KYNA's role outside the central nervous system may supplement the knowledge about the changes occurring during the pregnancy.