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Increased pro-inflammatory cytokines (TNF-alpha and IL-6) and anti-inflammatory compounds (sTNFRp55 and sTNFRp75) in Brazilian patients during exanthematic dengue fever.
- Source :
-
Memorias do Instituto Oswaldo Cruz [Mem Inst Oswaldo Cruz] 1999 May-Jun; Vol. 94 (3), pp. 387-94. - Publication Year :
- 1999
-
Abstract
- Pro-inflammatory cytokines, tumor necrosis factor (TNF-alpha), interleukin-6 (IL-6) and interleukin-1beta (IL-1beta) as well as anti-inflammatory compounds, soluble TNF-Receptor p55 (sTNFRp55), sTNFRp75 and IL-1 receptor antagonist (sIL-1Ra), were investigated in 34 Brazilian cases of dengue fever (DF) originated from a study of exanthematic virosis. The presence of pro-inflammatory cytokines was detected in sera from these patients by ELISA. TNF-alpha and IL-6 levels were significantly higher than control subjects in 32% and 52% patients, respectively. To our knowledge this was the first time a receptor antagonist and soluble receptors for cytokines were detected in sera obtained during exanthematic DF without hemorrhagic manifestations. Both sTNFRp55 and sTNFRp75 were consistently elevated in 42% and 84% patients, respectively. Most patients had IL-1beta levels not different from those of normal subjects, except for one case. Only 16% patients had altered levels of IL-1Ra. Previous studies in dengue hemorrhagic fever patients demonstrated production of these soluble factors; here we observed that they are found in absence of hemorrhagic manifestations. The possible role of these anti-inflammatory compounds in immune cell activation and in regulating cytokine-mediated pathogenesis during dengue infection is discussed.
- Subjects :
- Adult
Antigens, CD metabolism
Brazil
Dengue blood
Female
Humans
Interleukin-6 metabolism
Male
Middle Aged
Receptors, Tumor Necrosis Factor metabolism
Receptors, Tumor Necrosis Factor, Type I
Receptors, Tumor Necrosis Factor, Type II
Tumor Necrosis Factor-alpha metabolism
Antigens, CD blood
Dengue metabolism
Exanthema
Interleukin-6 blood
Receptors, Interleukin-1 antagonists & inhibitors
Receptors, Tumor Necrosis Factor blood
Tumor Necrosis Factor-alpha analysis
Subjects
Details
- Language :
- English
- ISSN :
- 0074-0276
- Volume :
- 94
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Memorias do Instituto Oswaldo Cruz
- Publication Type :
- Academic Journal
- Accession number :
- 10348988
- Full Text :
- https://doi.org/10.1590/s0074-02761999000300019