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A metaregression analysis of the dose-response effect of aspirin on stroke.
- Source :
-
Archives of internal medicine [Arch Intern Med] 1999 Jun 14; Vol. 159 (11), pp. 1248-53. - Publication Year :
- 1999
-
Abstract
- Background: We evaluated whether the risk of stroke depends on aspirin dose in patients with a previous transient ischemic attack or stroke.<br />Methods: We conducted a metaregression analysis of stroke by using published randomized, placebo-controlled trials. We analyzed studies of patients who had recently had a transient ischemic attack or stroke (ie, secondary prevention). We abstracted data on the treatment regimen and stroke. To evaluate the dose-response relationship, we conducted a metaregression analysis of study-specific risk ratios by means of weighted linear regression.<br />Results: Eleven randomized, placebo-controlled trials contributed a total of 5228 patients randomized to aspirin only and 4401 patients randomized to placebo only. The slope of the dose-response curve was virtually flat across a wide range of aspirin doses from 50 to 1500 mg/d (P = .49 for test of slope not =0). Summarizing across studies, aspirin decreases the risk of stroke by about 15% (risk ratio, 0.85;95% confidence interval, 0.77-0.94).<br />Conclusions: Aspirin reduces the risk of stroke by approximately 15%, and this effect is uniform across aspirin doses from 50 to 1500 mg/d. The lowest effective aspirin dose has not yet been identified, but it could be lower than 50 mg/d.
- Subjects :
- Aged
Dose-Response Relationship, Drug
Female
Humans
Linear Models
Male
Middle Aged
Odds Ratio
Randomized Controlled Trials as Topic
Risk
Aspirin administration & dosage
Cerebrovascular Disorders prevention & control
Fibrinolytic Agents administration & dosage
Platelet Aggregation Inhibitors administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 0003-9926
- Volume :
- 159
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Archives of internal medicine
- Publication Type :
- Academic Journal
- Accession number :
- 10371234
- Full Text :
- https://doi.org/10.1001/archinte.159.11.1248