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Natural antioxidant, chlorogenic acid, protects against DNA breakage caused by monochloramine.
- Source :
-
Bioscience, biotechnology, and biochemistry [Biosci Biotechnol Biochem] 1999 Jul; Vol. 63 (7), pp. 1295-7. - Publication Year :
- 1999
-
Abstract
- Chlorogenic acid prevented a stepwise conversion of plasmid pUC18 DNA, from I-->form II-->form III, induced by 3 mM monochloramine with a half inhibition of 67.4 microM. Chlorogenic acid reacted with monochloramine in a time-dependent manner, and the reaction rate increased with decreasing pH. These results suggest that chlorogenic acid prevents genotoxicity of monochloramine in gastric mucosa.
- Subjects :
- Ammonium Chloride chemistry
DNA, Bacterial chemistry
DNA, Bacterial drug effects
Helicobacter pylori drug effects
Helicobacter pylori metabolism
Plasmids chemistry
Spectrophotometry, Ultraviolet
Antioxidants pharmacology
Chloramines antagonists & inhibitors
Chloramines toxicity
Chlorogenic Acid pharmacology
DNA Damage drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 0916-8451
- Volume :
- 63
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Bioscience, biotechnology, and biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- 10478457
- Full Text :
- https://doi.org/10.1271/bbb.63.1295