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Increased incidence of cycloguanil resistance in malaria cases entering France from Africa, determined as point mutations in the parasites' dihydrofolate-reductase genes.
- Source :
-
Annals of tropical medicine and parasitology [Ann Trop Med Parasitol] 1999 Jan; Vol. 93 (1), pp. 25-30. - Publication Year :
- 1999
-
Abstract
- The incidence of cycloguanil resistance in 501 Plasmodium falciparum isolates from individuals entering France from Africa was estimated by a method based on PCR-restriction-fragment-length polymorphisms. None of the subjects had taken antifol prophylaxis. Annual incidence of the resistance, detected as a point mutation at codon 108 in the parasite's dihydrofolate-reductase gene, increased from 19.8% in 1995 to 43.6% in 1997 (P < 0.001). The proportion of isolates found to be susceptible (i.e. wild-type) among travellers returning from the African countries known as Group 2 in France (i.e. Burkina Faso, Côte d'Ivoire, Gambia, Ghana, Guinea, Liberia, Madagascar, Mali, Mauritania, Niger, Senegal, Sierra Leone, Tchad and Togo) was reasonably high (62.9%) and much higher than in the other subjects returning from other identifiable countries in Africa (35.3%). The antimalarial prophylaxis recommended in France to those travelling to Group-2 countries, chloroquine-proguanil, therefore still seems reasonable, although cycloguanil resistance may seriously undermine the efficacy of this drug combination in the future.
- Subjects :
- Africa
Animals
Folic Acid Antagonists therapeutic use
France
Humans
Point Mutation
Polymerase Chain Reaction
Polymorphism, Restriction Fragment Length
Proguanil
Antimalarials therapeutic use
Drug Resistance
Genes, Protozoan
Malaria, Falciparum drug therapy
Plasmodium falciparum genetics
Tetrahydrofolate Dehydrogenase genetics
Triazines therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 0003-4983
- Volume :
- 93
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Annals of tropical medicine and parasitology
- Publication Type :
- Academic Journal
- Accession number :
- 10492668
- Full Text :
- https://doi.org/10.1080/00034989958762