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BN 80927: a novel homocamptothecin with inhibitory activities on both topoisomerase I and topoisomerase II.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 1999 Sep 06; Vol. 9 (17), pp. 2599-602. - Publication Year :
- 1999
-
Abstract
- BN 80927, a novel homocamptothecin derivative, inhibits both topoisomerase I and topoisomerase II mediated DNA relaxation and shows pronounced cytotoxicity against HT29, SKOV-3, DU145 and MCF7 human tumor cell lines.
- Subjects :
- Antineoplastic Agents chemistry
Camptothecin chemical synthesis
Camptothecin pharmacology
Drug Screening Assays, Antitumor
Enzyme Inhibitors chemistry
Humans
Tumor Cells, Cultured
Antineoplastic Agents pharmacology
Camptothecin analogs & derivatives
Enzyme Inhibitors pharmacology
Topoisomerase I Inhibitors
Topoisomerase II Inhibitors
Subjects
Details
- Language :
- English
- ISSN :
- 0960-894X
- Volume :
- 9
- Issue :
- 17
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 10498216
- Full Text :
- https://doi.org/10.1016/s0960-894x(99)00428-x