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Bronchopulmonary carcinoids: An analysis of 1,875 reported cases with special reference to a comparison between typical carcinoids and atypical varieties.
- Source :
-
Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia [Ann Thorac Cardiovasc Surg] 1999 Aug; Vol. 5 (4), pp. 211-9. - Publication Year :
- 1999
-
Abstract
- This study was undertaken to provide investigators working in this particular research field with extensive and useful basic information based on an analysis of a large reliable series of cases regarding tracheal and bronchopulmonary carcinoids and their atypical varieties. A statistical evaluation was carried out which included a total of 1,875 patients with tracheal and bronchopulmonary carcinoids; these were divided into two series, one of 1,595 patients with typical carcinoids and the other of 280 with atypical varieties. These two series were compared regarding various aspects, which included the male to female ratio, age distribution, clinical manifestations, successful preoperative diagnosis, diagnostic accuracy of representative procedures, sites of involvement, tumor size distribution, metastases, carcinoid syndrome, serotonin activity in patients with or without the syndrome, immunohistochemistry, electron microscopy, and postoperative prognosis of the patients. The comparative analyses between the two series disclosed statistically significant differences (p<0.01) regarding various viewpoints; among others, such a difference was proved in the average age, sites of involvement in the lung (central or peripheral), rates and sites of metastases, adrenocorticotrophic hormone (ACTH) production, the association rate of the carcinoid syndrome, and postoperative 5-year and 10-year survival rates (93.3% and 82.1% for the typical carcinoid series versus 68.8% and 58.6% for the atypical variety series: p<0.0001). The postoperative 5-year and 10-year survival rates in the other two groups of patients with or without metastases were likewise calculated and showed a statistically significant difference (72.8% and 52.8% for the former versus 98.3% and 95.4% for the latter: p<0.0001).
- Subjects :
- Adolescent
Adult
Aged
Aged, 80 and over
Bronchial Neoplasms epidemiology
Bronchial Neoplasms surgery
Carcinoid Tumor epidemiology
Carcinoid Tumor surgery
Chi-Square Distribution
Child
Female
Humans
Japan epidemiology
Lung Neoplasms epidemiology
Lung Neoplasms surgery
Lymphatic Metastasis
Male
Malignant Carcinoid Syndrome epidemiology
Malignant Carcinoid Syndrome pathology
Malignant Carcinoid Syndrome surgery
Middle Aged
Statistics, Nonparametric
Survival Rate
Tracheal Neoplasms epidemiology
Tracheal Neoplasms surgery
Bronchial Neoplasms pathology
Carcinoid Tumor pathology
Lung Neoplasms pathology
Tracheal Neoplasms pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1341-1098
- Volume :
- 5
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia
- Publication Type :
- Academic Journal
- Accession number :
- 10508944