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Uncoupling IL-2 signals that regulate T cell proliferation, survival, and Fas-mediated activation-induced cell death.
- Source :
-
Immunity [Immunity] 1999 Sep; Vol. 11 (3), pp. 281-8. - Publication Year :
- 1999
-
Abstract
- IL-2 is an important growth and survival factor for T lymphocytes but also sensitizes these cells to Fas-mediated activation-induced cell death (AICD). The molecular basis of these different effects of IL-2 was studied by introducing wild-type and mutant forms of the IL-2 receptor beta (IL-2Rbeta) chain that lacked specific signaling capacities into receptor-deficient T cells by retroviral gene transfer. Activation of Stat5 by IL-2 was found to be involved in T cell proliferation and promoted Fas ligand (FasL) expression and AICD. T cell survival was dependent on a receptor region that activated Akt and the expression of Bcl-2. Thus, distinct IL-2Rbeta chain signaling modules regulate T cell fate by stimulating growth and survival or by promoting apoptosis.
- Subjects :
- Animals
Cell Division
Cell Survival
Cells, Cultured
Fas Ligand Protein
Gene Transfer Techniques
Genetic Vectors
Humans
Interleukin-2 pharmacology
Lymphocyte Activation
Membrane Glycoproteins biosynthesis
Mice
Mice, Inbred C57BL
Mice, Knockout
Mutagenesis
Receptors, Interleukin-2 genetics
Retroviridae
T-Lymphocytes cytology
T-Lymphocytes drug effects
Apoptosis immunology
Interleukin-2 immunology
Signal Transduction immunology
T-Lymphocytes immunology
fas Receptor immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1074-7613
- Volume :
- 11
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Immunity
- Publication Type :
- Academic Journal
- Accession number :
- 10514006
- Full Text :
- https://doi.org/10.1016/s1074-7613(00)80103-x