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Dietary NaC1 during pregnancy and lactation: effect on brain angiotensin II receptors and behavior.
Dietary NaC1 during pregnancy and lactation: effect on brain angiotensin II receptors and behavior.
- Source :
-
Behavioral neuroscience [Behav Neurosci] 1999 Oct; Vol. 113 (5), pp. 1090-4. - Publication Year :
- 1999
-
Abstract
- Female rats were fed diets containing either a basal (0.12%), mid- (1%) or high (3%) level of NaCl during pregnancy and lactation. Plasma aldosterone was elevated approximately 5- and 15-fold in dams fed basal compared with either the mid- or high-NaCl diets at the end of both pregnancy and lactation (Postnatal Day 21), respectively. Dams fed basal diet and killed at the end of lactation had a higher density of angiotensin II receptors in the organum vasculosum laminae terminalis, paraventricular hypothalamus, and median preoptic nucleus than did rats fed either mid- or high-NaCl diets. Other dams, treated identically, were returned to rodent chow (approximately 0.2% NaCl) at the end of lactation for intake tests during the next week. Dams that had received basal diet did not differ from mid-NaCl and high-NaCl groups in sodium appetite induced by either acute sodium depletion or mineralocorticoid administration but showed the lowest spontaneous intake of NaCl solution.
Details
- Language :
- English
- ISSN :
- 0735-7044
- Volume :
- 113
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Behavioral neuroscience
- Publication Type :
- Academic Journal
- Accession number :
- 10571491