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The ordered visual transduction complex of the squid photoreceptor membrane.
- Source :
-
Molecular neurobiology [Mol Neurobiol] 1999 Aug; Vol. 20 (1), pp. 61-80. - Publication Year :
- 1999
-
Abstract
- The study of visual transduction has given invaluable insight into the mechanisms of signal transduction by heptahelical receptors that act via guanine nucleotide binding proteins (G-proteins). However, the cyclic-GMP second messenger system seen in vertebrate photoreceptor cells is not widely used in other cell types. In contrast, the retina of higher invertebrates, such as squid, offers an equally accessible transduction system, which uses the widespread second messenger chemistry of an increase in cytosolic calcium caused by the production of inositol-(1,4,5)-trisphosphate (InsP3) by the enzyme phospholipase C, and which may be a model for store-operated calcium influx. In this article, we highlight some key aspects of invertebrate visual transduction as elucidated from the combination of biochemical techniques applied to cephalopods, genetic techniques applied to flies, and electrophysiology applied to the horseshoe crab. We discuss the importance and applicability of ideas drawn from these model systems to the understanding of some general processes in signal transduction, such as the integration of the cytoskeleton into the signal transduction process and the possible modes of regulation of store-operated calcium influx.
- Subjects :
- Amino Acid Sequence
Animals
Cell Membrane physiology
Decapodiformes
Models, Molecular
Molecular Sequence Data
Protein Conformation
TRPC Cation Channels
Calcium Channels chemistry
Calcium Channels physiology
Photoreceptor Cells, Invertebrate chemistry
Photoreceptor Cells, Invertebrate physiology
Vision, Ocular physiology
Subjects
Details
- Language :
- English
- ISSN :
- 0893-7648
- Volume :
- 20
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Molecular neurobiology
- Publication Type :
- Academic Journal
- Accession number :
- 10595873
- Full Text :
- https://doi.org/10.1007/BF02741365