Back to Search
Start Over
REM sleep in depression is influenced by ethnicity.
- Source :
-
Psychiatry research [Psychiatry Res] 1999 Nov 08; Vol. 88 (2), pp. 95-105. - Publication Year :
- 1999
-
Abstract
- The influence of ethnicity on the manifestation of EEG sleep changes in depression was studied in 95 patients (21 African-Americans [AA], 17 Asians [AS], 37 Caucasians [C] and 20 Hispanics [H]) with unipolar major depression. Subjects were studied twice for 2 consecutive nights. On the second night of each 2-night session, placebo or scopolamine (1.5 microg/kg, IM, at 23.00 h) was administered. On the baseline (placebo) night, sleep architecture, sleep continuity and rapid eye movement (REM) sleep variables were generally comparable among the groups. However, REM sleep was less in AA and AS subjects than in C and H subjects. Furthermore, the distribution of REM sleep over the course of the night in AA and AS subjects differed significantly from that in the C and H groups. Although scopolamine significantly affected sleep continuity and REM sleep measures, no significant differential effects of scopolamine were observed. Because many antidepressants suppress REM sleep, the differences in baseline REM sleep observed might be related to the greater sensitivity of some ethnic-minority depressed patients to pharmacotherapy.
- Subjects :
- Adult
California
Depressive Disorder complications
Depressive Disorder metabolism
Double-Blind Method
Female
Humans
Male
Middle Aged
Mydriatics administration & dosage
Polysomnography
Scopolamine administration & dosage
Sleep drug effects
Black or African American psychology
Asian psychology
Depressive Disorder ethnology
Hispanic or Latino psychology
Mydriatics pharmacology
Scopolamine pharmacology
Sleep, REM drug effects
White People psychology
Subjects
Details
- Language :
- English
- ISSN :
- 0165-1781
- Volume :
- 88
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Psychiatry research
- Publication Type :
- Academic Journal
- Accession number :
- 10622346
- Full Text :
- https://doi.org/10.1016/s0165-1781(99)00080-3