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Hepatosplenic B-cell lymphoma associated with hemophagocytic syndrome: a case report.
- Source :
-
Journal of Korean medical science [J Korean Med Sci] 1999 Dec; Vol. 14 (6), pp. 671-4. - Publication Year :
- 1999
-
Abstract
- While T-cell non-Hodgkin's lymphoma (NHL) associated with hemophagocytic syndrome (HPS) has been frequently observed, B-cell NHL associated with HPS has been rarely reported. We report a case of hepatosplenic B-cell lymphoma associated with HPS in a 41-year-old woman who presented with fever of unknown origin. An abdominal CT scan revealed splenomegaly with focal splenic infarction. Splenectomy and a liver wedge biopsy showed sinusoidal-pattern infiltration of medium to large tumor cells with positive reaction to a B-lymphocyte marker. Findings on bone marrow examination showed proliferation of histiocytes with avid hemophagocytosis.
- Subjects :
- Adult
Antigens, CD analysis
Antineoplastic Combined Chemotherapy Protocols therapeutic use
Biomarkers, Tumor analysis
Bone Marrow Cells pathology
Female
Histiocytosis, Non-Langerhans-Cell pathology
Humans
Liver Neoplasms diagnostic imaging
Liver Neoplasms pathology
Lymphoma, B-Cell diagnostic imaging
Lymphoma, B-Cell pathology
Splenic Neoplasms diagnostic imaging
Splenic Neoplasms pathology
Splenomegaly diagnostic imaging
Tomography, X-Ray Computed
Histiocytosis, Non-Langerhans-Cell complications
Liver Neoplasms complications
Lymphoma, B-Cell complications
Splenic Neoplasms complications
Subjects
Details
- Language :
- English
- ISSN :
- 1011-8934
- Volume :
- 14
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Journal of Korean medical science
- Publication Type :
- Academic Journal
- Accession number :
- 10642947
- Full Text :
- https://doi.org/10.3346/jkms.1999.14.6.671