Back to Search
Start Over
Aflatoxin and liver cancer.
- Source :
-
Bailliere's best practice & research. Clinical gastroenterology [Baillieres Best Pract Res Clin Gastroenterol] 1999 Dec; Vol. 13 (4), pp. 545-55. - Publication Year :
- 1999
-
Abstract
- This chapter reviews the data that have been accumulated implicating aflatoxin ingestion as an important risk factor in the aetiology of hepatocellular carcinoma (HCC). Numerous epidemiological studies have observed a correlation between areas of high aflatoxin exposure and a high incidence of HCC. The use of experimental models and specific biomarkers for aflatoxin exposure, such as urinary metabolites or aflatoxin adducts, have validated these findings. Ongoing clinical trials in Qidong, China, have indicated that oltipraz, a chemopreventive agent, can lower the biologically effective dose of aflatoxins by decreasing the metabolism of aflatoxin to its carcinogenic form and increasing the detoxification pathways of these metabolites. Intervention with chemicals such as these, alongside hepatitis B virus immunization programmes and improved storage conditions of staple foods, are prevention measures that can be undertaken to reduce the incidence of HCC in high-risk regions.
- Subjects :
- Animals
Anticarcinogenic Agents therapeutic use
Carcinoma, Hepatocellular epidemiology
Carcinoma, Hepatocellular genetics
Carcinoma, Hepatocellular prevention & control
China epidemiology
Environmental Exposure adverse effects
Genes, p53 genetics
Humans
Incidence
Liver Neoplasms epidemiology
Liver Neoplasms genetics
Liver Neoplasms prevention & control
Mutation
Pyrazines therapeutic use
Thiones
Thiophenes
Aflatoxins adverse effects
Carcinoma, Hepatocellular chemically induced
Liver Neoplasms chemically induced
Subjects
Details
- Language :
- English
- Volume :
- 13
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Bailliere's best practice & research. Clinical gastroenterology
- Publication Type :
- Academic Journal
- Accession number :
- 10654919
- Full Text :
- https://doi.org/10.1053/bega.1999.0047