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T-cell receptor gamma and delta gene rearrangements in T-cell acute lymphoblastic leukemia in Indian patients.
- Source :
-
Leukemia & lymphoma [Leuk Lymphoma] 2000 Jan; Vol. 36 (3-4), pp. 331-8. - Publication Year :
- 2000
-
Abstract
- T-cell acute lymphoblastic leukemia (T-ALL) is a clonal lymphoid malignancy and junctional sequences of rearranged T-cell receptor (TCR) represent the best suitable marker to study clonality in these patients. A sensitive, non-radioactive, and rapid approach of PCR coupled with heteroduplex analysis was used to analyse clonality of TCR gamma and delta gene rearrangements in 26 Indian T-ALL patients. Amongst TCR gamma gene family, VgammaI-Jgamma1.3/2.3 sequences were most utilized (53.9%) while from TCRdelta repertoire Vdelta1-Jdelta1 sequences were preferentially rearranged (23.1%) in these patients. 19.2% of Indian T-ALL patients demonstrated both clonal TCR gamma and delta gene rearrangements along with surface expression of TCRgammadelta. Although the majority of T-ALL patients showed surface expression of TCRalphabeta, the small fraction (19.2%) of TCRgammadelta+ T-ALL represent a distinct subgroup which needs further evaluation.
- Subjects :
- Adolescent
Adult
Age Factors
Aged
Antineoplastic Combined Chemotherapy Protocols therapeutic use
Child
Child, Preschool
Chlorambucil therapeutic use
Female
Humans
Immunophenotyping
India
Leukemia-Lymphoma, Adult T-Cell drug therapy
Leukemia-Lymphoma, Adult T-Cell immunology
Leukemia-Lymphoma, Adult T-Cell mortality
Male
Middle Aged
Mitoxantrone therapeutic use
Prednisolone therapeutic use
Sex Factors
Gene Rearrangement, delta-Chain T-Cell Antigen Receptor
Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor
Leukemia-Lymphoma, Adult T-Cell genetics
T-Lymphocytes immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1042-8194
- Volume :
- 36
- Issue :
- 3-4
- Database :
- MEDLINE
- Journal :
- Leukemia & lymphoma
- Publication Type :
- Academic Journal
- Accession number :
- 10674905
- Full Text :
- https://doi.org/10.3109/10428190009148854