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Mitotic misregulation and human aging.
- Source :
-
Science (New York, N.Y.) [Science] 2000 Mar 31; Vol. 287 (5462), pp. 2486-92. - Publication Year :
- 2000
-
Abstract
- Messenger RNA levels were measured in actively dividing fibroblasts isolated from young, middle-age, and old-age humans and humans with progeria, a rare genetic disorder characterized by accelerated aging. Genes whose expression is associated with age-related phenotypes and diseases were identified. The data also suggest that an underlying mechanism of the aging process involves increasing errors in the mitotic machinery of dividing cells in the postreproductive stage of life. We propose that this dysfunction leads to chromosomal pathologies that result in misregulation of genes involved in the aging process.
- Subjects :
- Adult
Aged
Aged, 80 and over
Aging pathology
Biochemical Phenomena
Cell Division
Cell Line
Cell Nucleus ultrastructure
Child
Chromosome Segregation genetics
Disease etiology
Extracellular Matrix metabolism
Female
Fibroblasts cytology
Humans
Male
Middle Aged
Mutation
Oligonucleotide Array Sequence Analysis
Phenotype
Progeria pathology
RNA, Messenger genetics
RNA, Messenger metabolism
Spindle Apparatus metabolism
Transcription Factors genetics
Aging genetics
Fibroblasts metabolism
Gene Expression Profiling
Gene Expression Regulation
Mitosis genetics
Progeria genetics
Subjects
Details
- Language :
- English
- ISSN :
- 0036-8075
- Volume :
- 287
- Issue :
- 5462
- Database :
- MEDLINE
- Journal :
- Science (New York, N.Y.)
- Publication Type :
- Academic Journal
- Accession number :
- 10741968
- Full Text :
- https://doi.org/10.1126/science.287.5462.2486