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Antihypertensive efficacy of manidipine and enalapril in hypertensive diabetic patients.
- Source :
-
Journal of cardiovascular pharmacology [J Cardiovasc Pharmacol] 2000 Jun; Vol. 35 (6), pp. 926-31. - Publication Year :
- 2000
-
Abstract
- Recent studies showed that in diabetic hypertensive patients, administration of angiotensin-converting enzyme (ACE)-inhibitors or calcium antagonists can effectively lower blood pressure (BP) and prevent diabetes-related cardiovascular complications with no adverse metabolic effects. We sought to assess the antihypertensive and metabolic effects of the new dihydropyridine calcium antagonist manidipine (M) in patients with diabetes mellitus and essential hypertension as compared with the ACE inhibitor enalapril (E). After 3 weeks of placebo, 101 (62 men; age range, 34-72 years) hypertensives with type II diabetes mellitus were randomized to M 10-20 mg or E 10-20 mg, od, for 24 weeks. At the end of the placebo period and the active-treatment phase, BP was measured with a mercury sphygmomanometer (office, O) and over the 24 h by ambulatory (A) monitoring. ABP recordings were analyzed to obtain 24-h, day (6 a.m. to midnight), and night (midnight to 6 a.m.) average systolic (S) and diastolic (D) BP and heart rate (HR) values. Homogeneity of the antihypertensive effect over the 24 h was assessed by the smoothness index [SI: i.e., the ratio between the average of the 24 hourly BP changes after treatment and the corresponding standard deviation (the higher the SI, the more uniform is the BP control by treatment over the 24 h]. The O SBP and DBP were significantly (p < 0.01) and similarly reduced by M (16 +/- 10 and 13 +/- 6 mm Hg, n = 49) and E (15 +/- 10 and 13 +/- 6 mm Hg, n = 45). The percentage of patients whose O DBP was reduced < or = 85 mm Hg (i.e., the value indicated to be the optimal DBP goal in diabetic hypertensives) was similar for M (37%) and E (40%). The reduction of 24-h BP also was similar between M (n = 38) and E (n = 38) for both drugs (systolic, 6 +/- 11 and 8 +/- 10 mm Hg; diastolic, 5 +/- 8 and 5 +/- 7; NS, M vs. E). The antihypertensive effect was distributed in a similar homogeneous fashion throughout the dosing interval, as shown by the similar SI values (M, 0.6 +/- 1.2 for SBP and 0.6 +/- 0.9 for DBP; E, 0.6 +/- 0.8 for SBP and 0.5 +/- 0.7 for DBP; NS, M vs. E). O and A HR were unchanged by either treatment. Markers of glucose and lipid metabolism and renal function were not significantly modified by treatment both with M and with E. In the diabetic hypertensives, M was as effective and metabolically neutral as the ACE-inhibitor E.
- Subjects :
- Adult
Aged
Blood Glucose drug effects
Blood Glucose metabolism
Blood Pressure drug effects
Blood Pressure Monitoring, Ambulatory
Cholesterol metabolism
Cholesterol, LDL drug effects
Cholesterol, LDL metabolism
Diabetes Mellitus, Type 2 complications
Diabetes Mellitus, Type 2 physiopathology
Diastole
Double-Blind Method
Glycated Hemoglobin drug effects
Glycated Hemoglobin metabolism
Heart Rate drug effects
Humans
Hypertension complications
Hypertension physiopathology
Male
Middle Aged
Nitrobenzenes
Piperazines
Systole
Treatment Outcome
Triglycerides metabolism
Uric Acid metabolism
Angiotensin-Converting Enzyme Inhibitors therapeutic use
Antihypertensive Agents therapeutic use
Diabetes Mellitus, Type 2 drug therapy
Dihydropyridines therapeutic use
Enalapril therapeutic use
Hypertension drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 0160-2446
- Volume :
- 35
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Journal of cardiovascular pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 10836728
- Full Text :
- https://doi.org/10.1097/00005344-200006000-00015