Back to Search
Start Over
Transient increase in mitogen-induced lymphoproliferative responses in patients with testicular cancer after BEP chemotherapy.
- Source :
-
Urology [Urology] 2000 Jun; Vol. 55 (6), pp. 934-8. - Publication Year :
- 2000
-
Abstract
- Objectives: To investigate the impact of polychemotherapy on cellular immunity in patients with testicular cancer.<br />Methods: Lymphocyte subpopulations, lymphoproliferative responses to mitogenic stimulation, and mitogen-induced release of soluble interleukin-2 receptor from peripheral blood mononuclear cells were investigated in 15 patients with testicular germ cell tumors a median of 61 months (range 7 to 73) after polychemotherapy with bleomycin, etoposide, and cisplatin (BEP).<br />Results: The numbers of peripheral blood T cells (CD3+), CD4+ and CD8+ subsets, and lymphoproliferative responses to pokeweed mitogen, phytohemagglutinin, and concanavalin A in patients were comparable to those of healthy control subjects. When two groups of patients were formed according to elapsed time from BEP polychemotherapy and study onset (group A, 12 months and group B, 69 months after termination of BEP), a significant increase in lymphoproliferative response to concanavalin A (P <0.05) was found in group A 1 year after chemotherapy.<br />Conclusions: BEP chemotherapy administered to patients with testicular cancer does not result in impairment of cellular immunity but rather leads to a significant increase in the capacity of patients' lymphocytes to respond to mitogenic stimulation up to 1 year after polychemotherapy. Moreover, the increased T-cell activity found after BEP therapy may contribute to the high rate of long-term complete remission.
- Subjects :
- Bleomycin administration & dosage
Cisplatin administration & dosage
Concanavalin A
Etoposide administration & dosage
Humans
Immunity, Cellular
Lectins
Male
Receptors, Interleukin-2
Antineoplastic Combined Chemotherapy Protocols therapeutic use
Germinoma drug therapy
Germinoma immunology
Leukocytes, Mononuclear
Lymphocyte Activation
Testicular Neoplasms drug therapy
Testicular Neoplasms immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0090-4295
- Volume :
- 55
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Urology
- Publication Type :
- Academic Journal
- Accession number :
- 10840113
- Full Text :
- https://doi.org/10.1016/s0090-4295(00)00524-0