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An abnormal cholesterol profile in young adults with normocholesterolemic cerebral ischemia.

Authors :
Chen WH
Lan MY
Chang YY
Liu JS
Source :
The Kaohsiung journal of medical sciences [Kaohsiung J Med Sci] 2000 Mar; Vol. 16 (3), pp. 141-7.
Publication Year :
2000

Abstract

An abnormal cholesterol fraction can still be able to provoke cascades of lipidic atherogenesis even when the serum TC level is within normal range (< 200 mg%). However, there is a shortage of convincing data concerning cerebral atherogenesis in young Asians who have a different diet habit and living style from those in western countries. In this study, we examined the lipoprotein-cholesterol profile in young Taiwanese patients with noncardiac cerebral ischemia (NCCI) whose serum TC level was < 200 mg% and 200-250 mg%. The results showed a decrease of HDLC and an increase of VLDLC in patients with TC < 200 mg%, but only a decrease of HDLC in patients with TC = 200-250 mg%. The cholesterol fraction metabolism is obviously perplexed in NCCI subjects. These findings were not related to their associated risk factors. Accordingly, a derangement of cholesterol fraction with normal serum TC level can also incite lipidic cerebral atherogenesis in young Taiwanese adults. Therefore, a detailed evaluation of cholesterol profile should be born in mind in young eastern NCCI patients despite of a normal serum TC level. Tailored measure of diet and living should be modified to prevent lipidic atherogenesis in our society in future.

Details

Language :
English
ISSN :
1607-551X
Volume :
16
Issue :
3
Database :
MEDLINE
Journal :
The Kaohsiung journal of medical sciences
Publication Type :
Academic Journal
Accession number :
10846350