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A morphological and immunohistological study of the human and rabbit appendix for comparison with the avian bursa.
A morphological and immunohistological study of the human and rabbit appendix for comparison with the avian bursa.
- Source :
-
Developmental and comparative immunology [Dev Comp Immunol] 2000 Dec; Vol. 24 (8), pp. 797-814. - Publication Year :
- 2000
-
Abstract
- Diversification of the primary antibody repertoire occurs in young rabbit appendix. As a prelude to molecular investigation of whether human appendix has a similar role, we compared the lymphoid morphology and distribution of common B- and T-cell subsets in frozen and/or paraffin-embedded normal appendix specimens at various ages. IgA, IgM and IgG staining patterns were similar in frozen human and rabbit appendices. The elongated follicles of the young human and rabbit appendices regressed with age to resemble Peyer's patches. Although similar in morphology to the bursa, human and rabbit appendix follicles differ in that they do not involute completely with age and contain significant numbers of germinal center (GC) T cells although the number is low early in life. If the human appendix functions as a primary lymphoid organ, it may occur during the first few months of age when the GC T-cell density is low.
- Subjects :
- ADP-ribosyl Cyclase
ADP-ribosyl Cyclase 1
Adolescent
Adult
Age Factors
Aged
Aged, 80 and over
Animals
Antigens, Differentiation analysis
B-Lymphocytes immunology
CD4 Antigens analysis
CD8 Antigens analysis
Chickens
Child
Child, Preschool
Germinal Center immunology
Humans
Immunoglobulins analysis
Immunohistochemistry
Infant
Infant, Newborn
Ki-67 Antigen analysis
Lymphocyte Count
Lymphoid Tissue growth & development
Membrane Glycoproteins
Middle Aged
NAD+ Nucleosidase analysis
Rabbits
T-Lymphocytes immunology
Trihexosylceramides analysis
Antigens, CD
Appendix immunology
Bursa of Fabricius immunology
Lymphoid Tissue immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0145-305X
- Volume :
- 24
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Developmental and comparative immunology
- Publication Type :
- Academic Journal
- Accession number :
- 10906392
- Full Text :
- https://doi.org/10.1016/s0145-305x(00)00033-1