Back to Search Start Over

[Synthesis and antioxidant activity of azole derivatives of hemin].

Authors :
Rozhkova EA
Lysko AI
Kuleshov KV
Evstigneeva RP
Source :
Bioorganicheskaia khimiia [Bioorg Khim] 2000 Jun; Vol. 26 (6), pp. 466-70.
Publication Year :
2000

Abstract

New derivatives of proto- and deuterohemin IX containing tri- and tetrazole rings were synthesized and characterized. A pronounced antioxidant activity was found for these compounds in the Fe(II)/ascorbate-dependent system of lipid peroxidation in murine liver homogenates.

Subjects

Subjects :
Animals
Antioxidants chemistry
Hemin chemistry
Lipid Peroxidation drug effects
Liver drug effects
Liver metabolism
Mice
Rats
Antioxidants chemical synthesis
Antioxidants pharmacology
Azoles chemistry
Hemin chemical synthesis
Hemin pharmacology

Details

Language :
Russian
ISSN :
0132-3423
Volume :
26
Issue :
6
Database :
MEDLINE
Journal :
Bioorganicheskaia khimiia
Publication Type :
Academic Journal
Accession number :
10923196

Tools

Authors Abstract Subjects Details