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Skin manifestations of a case of phenylbutazone-induced serum sickness-like reactions.
- Source :
-
Journal of investigational allergology & clinical immunology [J Investig Allergol Clin Immunol] 2000 May-Jun; Vol. 10 (3), pp. 170-2. - Publication Year :
- 2000
-
Abstract
- Serum sickness consists of a systemic reaction resulting from the formation of soluble circulating immunocomplexes after the introduction of a foreign substance into the body We studied a 38-year-old woman diagnosed with anxiety, depression and right sacroileitis who was treated with phenylbutazone, ranitidine, clomipramine and levomepromazine. After taking this treatment for 1 month, she presented with fever, diarrhea, localized edemas, generalized pruritic papular and erythematous rash and lymphadenopathies. She presented the same symptoms after oral intake of metamizole. The diagnosis was confirmed following a single-blind, placebo-controlled provocation test with phenylbutazone and a biopsy of the affected skin.
- Subjects :
- Adult
Anti-Inflammatory Agents, Non-Steroidal therapeutic use
Anxiety complications
Anxiety drug therapy
Depression complications
Depression drug therapy
Drug Hypersensitivity etiology
Exanthema diagnosis
Exanthema pathology
Exanthema therapy
Female
Humans
Lymphatic Diseases diagnosis
Lymphatic Diseases pathology
Lymphatic Diseases therapy
Phenylbutazone therapeutic use
Anti-Inflammatory Agents, Non-Steroidal adverse effects
Exanthema chemically induced
Lymphatic Diseases chemically induced
Phenylbutazone adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 1018-9068
- Volume :
- 10
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Journal of investigational allergology & clinical immunology
- Publication Type :
- Academic Journal
- Accession number :
- 10923593