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Modification of acquired immunity in BALB/c mice by aztreonam.
- Source :
-
International journal of antimicrobial agents [Int J Antimicrob Agents] 2000 Aug; Vol. 15 (3), pp. 193-9. - Publication Year :
- 2000
-
Abstract
- Recent studies have suggested that antibiotics may act as biological response modifiers. In this study we investigated the effect of aztreonam, a monobactam antibiotic, on different parameters of acquired immunity in BALB/c mice. Different dosages of aztreonam injected into mice induced an increase in the lymphoproliferative response to specific mitogens and in the production of interleukin-2 by splenic cells, as well as a decreased response of this immune population to sheep erythrocytes lower total blood cell counts and a lower percentage of monocytes than in untreated mice. These results show a modulatory action of aztreonam on different immune parameters, which is independent of its antimicrobial activity and that could be of interest in human therapy.
Details
- Language :
- English
- ISSN :
- 0924-8579
- Volume :
- 15
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- International journal of antimicrobial agents
- Publication Type :
- Academic Journal
- Accession number :
- 10926441
- Full Text :
- https://doi.org/10.1016/s0924-8579(00)00171-0