Synthesis of aminomethyl derivatives of 4-phenyl-1,2,4-triazolin-5-one-1-acetic acid amide and 3,4-diphenyl-1,2,4-triazolin-5-one-1-acetic acid amide.

Ehtyl esters of 4-phenyl-1,2,4-triazolin-5-one-1-acetic acid and 3,4-diphenyl-1,2,4-triazolin-5-one-1-acetic acid were transformed into the corresponding amides [Ia, b]. The aminomethylation reactions afforded Mannich bases [IIa, b-VIa, b] exhibiting the expected pharmacological effects.