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Animal models of exocrine pancreatic cancer.

Authors :
Hotz HG
Hines OJ
Foitzik T
Reber HA
Source :
International journal of colorectal disease [Int J Colorectal Dis] 2000 Jun; Vol. 15 (3), pp. 136-43.
Publication Year :
2000

Abstract

Clinically and biologically relevant animal models are mandatory to further evaluate both the pathophysiology and novel strategies for diagnosis and treatment of exocrine pancreatic cancer. This review briefly summarizes the features of human pancreatic cancer in order to define requirements for animal models of the disease. The described model systems in rodents include pancreatic cancer induced by chemicals, pancreatic cancer in transgenic, and immunodeficient animals.

Subjects

Subjects :
Animals
Animals, Genetically Modified
Cricetinae
Humans
Mice
Mice, SCID
Pancreatic Neoplasms chemically induced
Pancreatic Neoplasms veterinary
Rats
Reproducibility of Results
Research Design
Disease Models, Animal
Pancreatic Neoplasms physiopathology

Details

Language :
English
ISSN :
0179-1958
Volume :
15
Issue :
3
Database :
MEDLINE
Journal :
International journal of colorectal disease
Publication Type :
Academic Journal
Accession number :
10954185
Full Text :
https://doi.org/10.1007/s003840000229
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