Back to Search
Start Over
Synthesis and antifungal activity of novel pyrano[2',3':4,5]thiazolo[2,3-b]quinazolines, pyrido[2',3':4,5]thiazolo[2,3-b]quinazolines and pyrazolo[2',3':4,5]thiazolo[2,3-b]quinazolines.
- Source :
-
Farmaco (Societa chimica italiana : 1989) [Farmaco] 2000 Apr; Vol. 55 (4), pp. 287-92. - Publication Year :
- 2000
-
Abstract
- The starting materials thiazolo[2,3-b]quinazolines (5a,b) were obtained in one pot synthesis by treating octahydroquinazoline (2) with chloroacetic acid and aromatic aldehydes. Thiazoloquinazoline (5) was reacted with CH2(CN)2/piperidine and CH2(CN)2/NaOH (CH3OH), to furnish pyrano[2',3':4,5]thiazolo[2,3-b]quinazolines (6a,b) and pyrido[2',3':4,5]thiazolo[2,3-b]quinazoline (7), respectively. Refluxing of 5a with NH2CSNH2/KOH and hydrazines in ethanol furnished the corresponding, [1,3]thiazino[4'5':4,5]thiazolo[2,3-b]quinazoline (10) and pyrazolo[3',4':4,5]thiazolo[2,3-b]quinazolines (11a,b), respectively. Antifungal activity was shown for some of the synthesized compounds.
- Subjects :
- Antifungal Agents chemistry
Aspergillus flavus
Aspergillus ochraceus
Candida albicans
Microbial Sensitivity Tests
Molecular Structure
Penicillium chrysogenum
Pyrans chemical synthesis
Pyrans chemistry
Pyrazoles chemical synthesis
Pyrazoles chemistry
Pyridines chemical synthesis
Pyridines chemistry
Quinazolines chemical synthesis
Quinazolines chemistry
Thiazoles chemical synthesis
Thiazoles chemistry
Antifungal Agents pharmacology
Pyrans pharmacology
Pyrazoles pharmacology
Pyridines pharmacology
Quinazolines pharmacology
Thiazoles pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0014-827X
- Volume :
- 55
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Farmaco (Societa chimica italiana : 1989)
- Publication Type :
- Academic Journal
- Accession number :
- 10966160
- Full Text :
- https://doi.org/10.1016/s0014-827x(00)00042-2