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Cholinergic nerve fibres associated with the microvessels of the human cerebral cortex: a study based on monoclonal immunocytochemistry for choline acetyltrasferase.
- Source :
-
European journal of histochemistry : EJH [Eur J Histochem] 2000; Vol. 44 (2), pp. 165-9. - Publication Year :
- 2000
-
Abstract
- The distribution of cholinergic nerve fibres associated with the microvasculature of the human parietal cerebral cortex was investigated by immunocytochemistry, employing monoclonal antibodies against choline acetyl-transferase, the acetylcholine-synthesizing enzyme. The results revealed strongly immunoreactive nerve fibres in the tunica adventitia of arterioles penetrating the superficial cortical layers from the pial vasculature. Networks of stained nerve fibres were seen within the tunica muscularis of the radially directed arterioles that cross the intermediate and deep cortical laminae, and of their transverse and recurrent branches. Tiny positive nerve fibres were also seen around the cortex capillaries, some reaching the endothelial cells. The morphological data support the involvement of acetylcholine in microvasculature local regulation, possibly with a differentiated role in the arterioles and capillaries.
- Subjects :
- Antibodies, Monoclonal immunology
Arterioles pathology
Capillaries innervation
Cerebral Arteries pathology
Choline O-Acetyltransferase immunology
Humans
Immunoenzyme Techniques
Nerve Fibers pathology
Parietal Lobe pathology
Arterioles innervation
Cerebral Arteries innervation
Choline O-Acetyltransferase analysis
Nerve Fibers enzymology
Parietal Lobe blood supply
Subjects
Details
- Language :
- English
- ISSN :
- 1121-760X
- Volume :
- 44
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- European journal of histochemistry : EJH
- Publication Type :
- Academic Journal
- Accession number :
- 10968364