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The role of chromosomal RNAs in marking the X for dosage compensation.
- Source :
-
Current opinion in genetics & development [Curr Opin Genet Dev] 2000 Oct; Vol. 10 (5), pp. 555-61. - Publication Year :
- 2000
-
Abstract
- Both flies and mammals remodel the architecture of the X chromosome to achieve dosage compensation. A novel class of noncoding RNAs that paint entire chromosomes are centrally involved in this process. The genes encoding these unusual RNAs are themselves located on the X, and are key sites that target the X for dosage compensation.
- Subjects :
- Animals
Chromatin genetics
Chromatin metabolism
DNA-Binding Proteins
Drosophila melanogaster genetics
Drosophila melanogaster metabolism
Humans
Nuclear Proteins metabolism
RNA genetics
RNA, Long Noncoding
RNA-Binding Proteins metabolism
Transcription Factors genetics
Transcription Factors metabolism
Transcription Factors physiology
Dosage Compensation, Genetic
Drosophila Proteins
RNA physiology
RNA, Untranslated
X Chromosome genetics
Subjects
Details
- Language :
- English
- ISSN :
- 0959-437X
- Volume :
- 10
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Current opinion in genetics & development
- Publication Type :
- Academic Journal
- Accession number :
- 10980435
- Full Text :
- https://doi.org/10.1016/s0959-437x(00)00127-1