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Amiloride-sensitive signals and NaCl preference and appetite: a lick-rate analysis.
- Source :
-
American journal of physiology. Regulatory, integrative and comparative physiology [Am J Physiol Regul Integr Comp Physiol] 2000 Oct; Vol. 279 (4), pp. R1403-11. - Publication Year :
- 2000
-
Abstract
- Rats prefer hypotonic and isotonic NaCl solutions to water in long-access drinking paradigms. To focus on the role of taste signals in NaCl preference, licking patterns of rats with 30-s exposure to NaCl solutions (0-0.5 M) were examined when they were either water deprived, sodium depleted, or not deprived (NaCl mixed in dilute sucrose). In all three conditions, rats displayed a preference for NaCl. The addition of 100 microM amiloride, a sodium channel blocker, to NaCl did not change rats' licking when they were sodium replete but dramatically reduced licking when they were deplete. Transection of the chorda tympani (CT) nerve, an afferent pathway for amiloride-sensitive Na(+) signals, had no effect on NaCl preference in nondeprived rats and only a modest effect on those that were Na(+) deplete. Amiloride was found to exert significant suppression of NaCl intake in Na(+)-depleted rats with transection of the CT, supporting the existence of other afferent pathways for transmission of amiloride-sensitive Na(+) signalling. Together, these studies argue for the involvement of different neural signalling mechanisms in NaCl preference in the presence and absence of explicit Na(+) need.
- Subjects :
- Animals
Appetite drug effects
Dose-Response Relationship, Drug
Feeding Behavior drug effects
Feeding Behavior physiology
Food Preferences drug effects
Male
Rats
Rats, Wistar
Signal Transduction
Taste drug effects
Amiloride pharmacology
Appetite physiology
Food Preferences physiology
Sodium, Dietary
Taste physiology
Water Deprivation physiology
Subjects
Details
- Language :
- English
- ISSN :
- 0363-6119
- Volume :
- 279
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- American journal of physiology. Regulatory, integrative and comparative physiology
- Publication Type :
- Academic Journal
- Accession number :
- 11004010
- Full Text :
- https://doi.org/10.1152/ajpregu.2000.279.4.R1403