Back to Search
Start Over
Immune thrombocytopenic purpura in childhood in Norway: a prospective, population-based registration.
- Source :
-
Pediatric hematology and oncology [Pediatr Hematol Oncol] 2000 Oct-Nov; Vol. 17 (7), pp. 551-8. - Publication Year :
- 2000
-
Abstract
- A prospective, population-based registration of children with immune thrombocytopenic purpura (ITP) was performed in Norway in 1996 and 1997. Ninety-two cases were identified, indicating an incidence of 5.3 per 100,000 children under 15 years. The sex ratio (female/male) was 1.2/1. Fifty-six percent presented with cutaneous signs only. The lowest platelet count was < 20 x 10(9)/L in 91%. In spite of mild bleeding symptoms, medical treatment was given in 68%, in most cases (57/63) with intravenous immunoglobulin. A total of 41/44 patients with platelet counts of < or = 5 x 10(9)/L were treated, regardless of whether they had mucous bleedings or not. Eighteen percent had platelet counts < 150 x 10(9)/L at 6 months, and 9% at 12 months following diagnosis. One patient with therapy-resistant chronic ITP died 16 months after diagnosis from an anesthesia complication related to profound epistaxis. This study shows a relatively high incidence. As in other studies, there was a tendency to treat platelet counts rather than bleeding symptoms.
- Subjects :
- Adolescent
Age Factors
Bone Marrow pathology
Child
Child, Preschool
Erythrocyte Transfusion
Female
Humans
Incidence
Infant
Infant, Newborn
Male
Norway epidemiology
Platelet Count
Prospective Studies
Purpura, Thrombocytopenic, Idiopathic pathology
Purpura, Thrombocytopenic, Idiopathic therapy
Sex Factors
Purpura, Thrombocytopenic, Idiopathic epidemiology
Registries
Subjects
Details
- Language :
- English
- ISSN :
- 0888-0018
- Volume :
- 17
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Pediatric hematology and oncology
- Publication Type :
- Academic Journal
- Accession number :
- 11033730
- Full Text :
- https://doi.org/10.1080/08880010050122816