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[Role of nitric oxide in airway mucociliary dysfunction in diffuse panbronchiolitis].
- Source :
-
Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society [Nihon Kokyuki Gakkai Zasshi] 2000 Aug; Vol. 38 (8), pp. 585-8. - Publication Year :
- 2000
-
Abstract
- Nitric oxide (NO) stimulates the ciliary motility of the airway epithelium, thereby assisting in the regulation of mucociliary transport in the respiratory tract. In the present study, to elucidate a possible involvement of NO in mucociliary disturbance in diffuse panbronchiolitis (DPB), we measured nasal clearance time (NCT) using the saccharin test, NO concentration in the exhaled air with a chemiluminescence analyzer, and electrolyte concentration in the sputum. Compared with healthy nonsmokers and smokers, patients with DPB showed a lower NO concentration in the exhaled air (p < 0.05), prolonged NCT (p < 0.01), and a higher Cl concentration in the sputum (p < 0.05). Among these variables, exhaled NO concentration was negatively correlated with NCT (p < 0.01) and sputum Cl concentration (p < 0.05). These results suggest that the inhibition of NO generation associated with an elevated Cl concentration in the airway surface liquid may contribute to airway mucociliary dysfunction in DPB.
Details
- Language :
- Japanese
- ISSN :
- 1343-3490
- Volume :
- 38
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society
- Publication Type :
- Academic Journal
- Accession number :
- 11061082