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Computational model of the role of sensory disorganization in focal task-specific dystonia.
- Source :
-
Journal of neurophysiology [J Neurophysiol] 2000 Nov; Vol. 84 (5), pp. 2458-64. - Publication Year :
- 2000
-
Abstract
- We present a new computational model for the development of task-specific focal dystonia. The purpose of the model is to explain how altered sensory representations can lead to abnormal motor behavior. Dystonia is described as the result of excessive gain through a sensorimotor loop. The gain is determined in part by the sensory cortical area devoted to each motor function, and behaviors that lead to abnormal increases in sensory cortical area are predicted to lead to dystonia. Properties of dystonia including muscular co-contraction, overflow movements, and task specificity are predicted by properties of a linear approximation to the loop transformation. We provide simulations of several different mechanisms that can cause the gain to exceed 1 and the motor activity to become sustained and uncontrolled. The model predicts that normal plasticity mechanisms may contribute to worsening of symptoms over time.
- Subjects :
- Humans
Motor Cortex physiopathology
Motor Neurons physiology
Movement physiology
Neuronal Plasticity physiology
Posture physiology
Psychomotor Performance physiology
Volition physiology
Dystonic Disorders physiopathology
Models, Neurological
Neurons, Afferent physiology
Sensation Disorders physiopathology
Somatosensory Cortex physiology
Subjects
Details
- Language :
- English
- ISSN :
- 0022-3077
- Volume :
- 84
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Journal of neurophysiology
- Publication Type :
- Academic Journal
- Accession number :
- 11067988
- Full Text :
- https://doi.org/10.1152/jn.2000.84.5.2458