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The ACE I/D polymorphism and human physical performance.
- Source :
-
Trends in endocrinology and metabolism: TEM [Trends Endocrinol Metab] 2000 Dec; Vol. 11 (10), pp. 416-20. - Publication Year :
- 2000
-
Abstract
- The D allele of the angiotensin-converting enzyme (ACE) I/D polymorphism is associated with elevated levels of serum and tissue ACE, increased production of the vasopressor angiotensin II and a reduction in the half-life of the vasodilator bradykinin. Several cardiac and renal conditions appear to have a worse prognosis in subjects homozygous for the D allele, whereas the I allele has been associated with enhanced endurance performance in elite distance runners, rowers and mountaineers. The nature of the gene-environment interaction between ACE I/D polymorphisms and physical training, an overview of recent findings and a discussion of possible underlying mechanisms is the subject of this review.
Details
- Language :
- English
- ISSN :
- 1043-2760
- Volume :
- 11
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Trends in endocrinology and metabolism: TEM
- Publication Type :
- Academic Journal
- Accession number :
- 11091119
- Full Text :
- https://doi.org/10.1016/s1043-2760(00)00310-6